Discontinue use if severe or prolonged diarrhea develops. Avoid sexual intercourse during therapy. May result in overgrowth of nonsusceptible organisms particularly yeasts. Women w/ immunodeficiency states or colitis; patients w/ inflammatory bowel disease particularly Crohn's disease or nonspecific ulcerative colitis. Not recommended to use latex or rubber products (eg, condoms or birth control vag diaphragms) during & w/in 72 hr after treatment; other products intended for intravag administration (eg, tampons, douching agents). Concomitant use w/ medicines suppressing peristalsis is contraindicated in case of severe or prolonged diarrhea. Investigate other infections including Trichomonas vaginalis, Candica albicans, Chlamydia trachomatis & gonococcal infections prior to or after initiation of therapy. Renal & hepatic impairment. Not recommended during 1st trimester of pregnancy. Lactation. Paed patients. Elderly >65 yr.
May enhance action of other neuromuscular blocking agents. Reduced contraceptive efficacy & protective properties from STDs of latex or rubber products eg, condoms or birth control vag diaphragms.
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