Co-amoxiclav (amoxicillin & clavulanic acid). Per 625 mg tab Amoxicillin 500 mg, clavulanic acid 125 mg. Per 1 g tab Amoxicillin 875 mg, clavulanic acid 125 mg. Per 600 mg vial Amoxicillin Na 500 mg, clavulanate K 100 mg. Per 1.2 g vial Amoxicillin Na 1 g, clavulanate K 200 mg
Indications/Uses
Treatment of infections caused by susceptible gm +ve & gm -ve microorganisms.
Dosage/Direction for Use
Tab Adult & childn ≥40 kg 625 mg 12 hrly or 375 mg 8 hrly. More severe & resp tract infections 1 g 12 hrly or 625 mg 8 hrly. Inj Adult & childn >12 yr 1.2 g 8 hrly. Serious infections 6 hrly. Childn 3 mth-12 yr 30 mg/kg 8 hrly. Serious infections 6 hrly. Childn 0-3 mth 30 mg/kg 12 hrly in premature infants & 8 hrly in full-term infants during perinatal period. Surgical prophylaxis 1.2 g IV at anesth induction. High-risk infection eg, colorectal surgery 3-4 doses of 1.2 g in 24-hr period (at 0, 8, 16 & 24 hr).
Administration
May be taken with or without food: Take at the start of a meal for better absorption & to minimize GI intolerance.
Contraindications
Penicillin hypersensitivity. Possible cross-sensitivity w/ other β-lactam antibiotics eg, cephalosporins. History of penicillin-associated jaundice/hepatic dysfunction.
Special Precautions
Hepatic dysfunction, moderate to severe renal impairment. Periodic assessment of hepatic, renal & hematopoietic function during prolonged therapy or in patients w/ severe hepatic impairment. Maintain adequate fluid intake & urinary output especially in high doses of amoxicillin. Avoid prolonged use. Prolonged bleeding & prothrombin time. Concomitant use w/ anticoagulants. Pregnancy & lactation.
Adverse Reactions
Diarrhea, pseudomembranous colitis, indigestion, vomiting, mucocutaneous candidiasis, nausea, hepatitis, cholestatic jaundice. Moderate & asymptomatic rise in AST, ALT or alkaline phosphatase; urticarial & erythematous skin rashes; transient leukopenia & thrombocytopenia. Inj: Local irritation, induration & phlebitis at inj site.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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