Initially 5 mg once daily. May administer 10 mg daily when daily dose has been 5 mg for 4-6 wk. Patient established on 10 mg daily for at least 3 mth 23 mg once daily in the evening prior to retiring.
Exaggerated succinylcholine-type muscle relaxation during anesth. Vagotonic effects on SA or AV nodes; syncopal episodes. Nausea & vomiting. PUD & GI bleeding; history of ulcer disease or concomitant use w/ NSAIDs. Wt loss. Bladder outflow obstruction. May cause generalized convulsions. History of asthma or obstructive pulmonary disease. Lower wt individuals. Pregnancy & lactation. Childn.
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