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Dermal necrosis associated with norepinephrine IV infusion
Adult: As phentolamine mesilate: Prevention: 10 mg is added to each litre of solution containing norepinephrine. Treatment of extravasation of norepinephrine: 5-10 mg (diluted in 10 mL 0.9% NaCl) is injected via local infiltration into the affected area within 12 hours.
Intramuscular, Intravenous
Diagnosis of phaeochromocytoma
Adult: Reserved for cases in which additional confirmatory test is necessary and after risks associated with use have been considered: As phentolamine mesilate: Recommended dose: 5 mg via rapid IV inj (after pressor response to venipuncture has subsided) or IM inj. Record blood pressure immediately after inj, every 30 seconds for the 1st 3 minutes, then every 1 minute for the next 7 minutes (IV inj); or every 5 minutes for 30-45 minutes (IM inj). Patient must rest in a supine position during the test preferably in a quiet, darkened room. Delay the inj until blood pressure is stabilised by monitoring every 10 minutes for at least 30 minutes. Withhold analgesics, sedatives and all other medications except for essential drugs (e.g. digitalis, insulin) for at least 24 hours and preferably 48-72 hours before the test. Refer to the detailed product or local guideline for interpretation of response.
Child: Reserved for cases in which additional confirmatory test is necessary and after risks associated with use have been considered: As phentolamine mesilate: Recommended dose: 1 mg via rapid IV inj (after pressor response to venipuncture has subsided) or 3 mg via IM inj. Record blood pressure immediately after IV inj, at 30-second intervals for the 1st 3 minutes, then at 60-second intervals for the next 7 minutes; or every 5 minutes for 30-45 minutes after IM inj. Patient must rest in a supine position during the test preferably in a quiet, darkened room. Delay the inj until blood pressure is stabilised by checking every 10 minutes for at least 30 minutes. Withhold analgesics, sedatives and all other medications except for essential drugs (e.g. digitalis, insulin) for at least 24 hours and preferably 48-72 hours before the test. Refer to the detailed product or local guideline for interpretation of response.
Child: Reserved for cases in which additional confirmatory test is necessary and after risks associated with use have been considered: As phentolamine mesilate: Recommended dose: 1 mg via rapid IV inj (after pressor response to venipuncture has subsided) or 3 mg via IM inj. Record blood pressure immediately after IV inj, at 30-second intervals for the 1st 3 minutes, then at 60-second intervals for the next 7 minutes; or every 5 minutes for 30-45 minutes after IM inj. Patient must rest in a supine position during the test preferably in a quiet, darkened room. Delay the inj until blood pressure is stabilised by checking every 10 minutes for at least 30 minutes. Withhold analgesics, sedatives and all other medications except for essential drugs (e.g. digitalis, insulin) for at least 24 hours and preferably 48-72 hours before the test. Refer to the detailed product or local guideline for interpretation of response.
Intramuscular, Intravenous
Hypertension in phaeochromocytoma
Adult: As phentolamine mesilate: For prevention or control of cases: Preoperative reduction of elevated blood pressure: 5 mg via IV or IM inj given 1 or 2 hours prior to surgery, may be repeated if necessary. During surgery: 5 mg via IV inj as indicated.
Child: As phentolamine mesilate: For prevention or control of cases: Preoperative reduction of elevated blood pressure: 1 mg via IV or IM inj given 1 or 2 hours prior to surgery, may be repeated if necessary. During surgery: 1 mg via IV inj as indicated.
Child: As phentolamine mesilate: For prevention or control of cases: Preoperative reduction of elevated blood pressure: 1 mg via IV or IM inj given 1 or 2 hours prior to surgery, may be repeated if necessary. During surgery: 1 mg via IV inj as indicated.
