Palivizumab: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Intramuscular
Passive immunisation of infants against lower respiratory tract infections

Child: <2 yr 15 mg/kg mthly during the season of resp syncytial virus (RSV) risk. Subsequent doses should be given mthly until the end of the season. Undergone cardiac bypass surgery: 15 mg/kg as soon as stable post-op. Admin preferably in the anterolateral thigh; vol >1 mL should be given in divided doses.

Contraindications

Hypersensitivity to palivizumab or other humanised monoclonal antibodies.

Special Precautions

Patient w/ thrombocytopenia or other coagulation disorder, moderate to severe acute infection or febrile illness. Not intended for use in adult. Pregnancy and lactation.

Adverse Reactions

Fever, inj site reactions, nervousness, diarrhoea, vomiting, constipation, haemorrhage, rhinitis, cough, wheeze, pain, drowsiness, asthenia, hyperkinesia, leucopenia, rash, apnoea, convulsions, thrombocytopenia.
Potentially Fatal: Anaphylaxis and anaphylactic shock.

Lab Interference

May cause false-negative result w/ immunological-based RSV diagnostic test e.g. some antigen detection based assay.

Action

Description: Palivizumab is a recombinant humanised monoclonal antibody which targets the surface glycoprotein, responsible for recognition and entry into the cell on the resp syncytial virus (RSV).
Pharmacokinetics:
Absorption: Well absorbed. Bioavailability: 70%.
Excretion: Elimination half-life: 24.5 days.

Storage

Store between 2-8°C. Do not freeze.

MIMS Class

Vaccines, Antisera & Immunologicals

References

Anon. Palivizumab. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/11/2014.

Buckingham R (ed). Respiratory Syncytial Virus Immunoglobulins. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/11/2014.

Joint Formulary Committee. Palivizumab. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/11/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Palivizumab. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 06/11/2014.

Synagis Injection, Solution (MedImmune, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/11/2014.

Synagis Injection. U.S. FDA. https://www.fda.gov/. Accessed 06/11/2014.

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