Nadifloxacin: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Myanmar prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Acne vulgaris

Adult: As 1% cream/gel: Apply to affected area bid. Discontinue treatment if desired effect is not achieved after 4 weeks.

Contraindications

Hypersensitivity to nadifloxacin or other fluoroquinolones.

Adverse Reactions

Skin and subcutaneous tissue disorders: Itching and erythema at application sites, pruritus, redness, flushing, feeling of facial warmth, papules, contact dermatitis, dry skin.

Action

Description: Nadifloxacin, a synthetic fluoroquinolone anti-infective agent, acts by inhibiting the bacterial DNA gyrase which is involved in DNA synthesis and replication, thus inhibiting bacterial multiplication
Pharmacokinetics:
Absorption: Time to peak plasma concentration: 8 hours (post-final dosing).
Excretion: Via urine (approx 0.09%). Elimination half-life: 19.4 hours.

Chemical Structure

Storage

Store below 30°C.

MIMS Class

Topical Antibiotics

ATC Classification

D10AF05 - nadifloxacin ; Belongs to the class of topical antiinfective preparations used in the treatment of acne.

References

Acuatim (Otsuka). MIMS Indonesia. http://mims.com/indonesia. Accessed 17/01/2020.

Anon. Nadifloxacin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 17/01/2020.

Buckingham R (ed). Nadifloxacin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 17/01/2020.

Nadibact (Cipla - Xterna). MIMS Philippines. http://mims.com/philippines. Accessed 17/01/2020.

Quinolones. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com/. Accessed 17/01/2020.

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