NIDDM or type 2 diabetes as an adjunct to diet & exercise to improve glycemic control. May be used concomitantly w/ sulfonylurea or insulin to improve glycemic control in adults. Metforlip IDDM as adjuvant therapy in combination w/ insulin. Metforlip SR IDDM as adjuvant therapy in combination w/ insulin in patients who are often obese.
MetforlipAdult & childn Initially 500 mg bd. Increase dose by increment of 500 mg wkly up to total of 2,000 mg daily, given in divided doses (bd-tds). Adults can be titrated from 500 mg bd to 850 mg bd after 2 wk. Metforlip SRAdult Initially 500 mg once daily. Increase dose by increment of 500 mg wkly up to max of 2,000 mg once daily. Consider 1,000 mg bd if glycemic control is not achieved.
Not to be used in patients w/ serum creatinine levels above ULN. Regularly monitor renal function. Stop therapy 2-3 days prior to surgery & clinical investigations (eg, IV urology, angiography). Perform annual estimation of vit B12 levels in patients on continuous therapy. Monitor blood glucose in concomitant use w/ sulfonylurea. Not recommended in childn. Elderly.