Patients w/ hemorrhagic disorders or those receiving anticoagulants or other drugs affecting coagulation. Monitor hepatic function in patients w/ hepatic impairment, particularly in high doses. Asthmatic patients sensitive to aspirin for potential effect on prostaglandin synthesis. Pregnancy & lactation.
Potential interaction w/ aspirin & other NSAIDs, & herbs (eg, garlic, ginkgo) which may be manifested by increased susceptibility to bruising, nosebleed, hemoptysis, hematemesis, hematuria & blood in the stool.