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Indications and Dosage
Oral
Hypertension Adult: 10-20 mg once daily.
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Administration
Should be taken with food. Take after breakfast.
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Contraindications
Cardiogenic shock; recent MI or acute unstable angina; severe aortic stenosis.
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Special Precautions
Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischaemic pain following administration. Pregnancy, lactation; porphyria.
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Adverse Reactions
Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.
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Drug Interactions
Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses. Plasma concentrations may be reduced by: carbamazepine, phenytoin, rifampicin. Plasma concentrations may be increased by cimetidine, erythromycin.
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Action
Description: Manidipine is a dihydropyridine calcium-channel blocker. It causes vasodilation by blocking the entry of calcium into the arteriolar muscle cells. Manidipine also appears to have some renally protective effects.
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MIMS Class
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