Zosaar HCT

Zosaar HCT

losartan + hydrochlorothiazide




Concise Prescribing Info
Losartan K 50 mg, hydrochlorothiazide 12.5 mg
HTN. Reduce risk of stroke in patients w/ HTN & left ventricular hypertrophy (LVH).
Dosage/Direction for Use
HTN Initial & maintenance dose: 1 tab once daily, may be increased to max: 2 tab once daily. Hypertensive patient w/ LVH Initially losartan 50 mg once daily, may be titrated w/ combination of losartan & hydrochlorothiazide 12.5 mg & if needed, may be increased to 100/12.5 mg or further increased to 100/25 mg once daily.
May be taken with or without food.
Hypersensitivity to losartan K, hydrochlorothiazide or other sulfonamide-derived drugs. Anuria.
Special Precautions
Hypersensitivity. Discontinue use if syncope occurs. Not to be initiated in intravascular vol-depleted patients (eg, those treated w/ high-dose diuretics). History of allergy or bronchial asthma; sulfonamide or penicillin allergy. SLE exacerbation or activation; acute myopia & secondary angle-closure glaucoma; fluid or electrolyte imbalance eg, hyponatremia, hypochloremic alkalosis & hypokalemia; non-melanoma skin cancer; precipitated hyperuricemia or gout; latent DM; hypomagnesemia; decreased urinary Ca excretion; intermittent & slightly increased serum Ca; increased cholesterol & triglyceride levels. Limit exposure to sunlight & UV rays. Correct symptomatic hypotension prior to treatment. Perform periodic determination of serum & urine electrolytes. Discontinue use prior to parathyroid function tests. Not to be used w/ K supplements or K-containing salt substitutes. Not recommended in hepatic or severe renal impairment (CrCl ≤30 mL/min). Progressive liver disease. Not to be used during pregnancy. Lactation. Childn. Not to be used for initial therapy in elderly.
Adverse Reactions
Asthenia/fatigue, diarrhea, nausea, headache, bronchitis, pharyngitis.
Drug Interactions
Losartan: Decreased conc by rifampin. Increased serum K w/ K-sparing diuretics (eg, spironolactone, triamterene, amiloride), K supplements or K-containing salt substitutes. Reduced lithium excretion. Attenuated antihypertensive effects by NSAIDs including selective COX-2 inhibitors. Closely monitor BP, renal function & electrolytes w/ ACE inhibitors. Hydrochlorothiazide: Potentiated orthostatic hypotension w/ alcohol, barbiturates or narcotics. Adjust dosage w/ oral antidiabetics & insulin. Additive effects w/ other antihypertensive drugs. Impaired absorption w/ cholestyramine & colestipol resins. Intensified electrolyte depletion w/ corticosteroids, ACTH or glycyrrhizin. Decreased response to pressor amines eg, norepinephrine. Increased responsiveness to nondepolarizing skeletal muscle relaxants eg, tubocurarine. Reduced renal clearance of lithium. Reduced diuretic, natriuretic & antihypertensive effects w/ NSAIDs including selective COX-2 inhibitors.
MIMS Class
Angiotensin II Antagonists / Diuretics
ATC Classification
C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.
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