Symptoms indicative of GI disorder, history of GI ulceration, ulcerative colitis, Crohn's disease, impaired cardiac function, patients on diuretics or recovery from major surgery. Monitor renal & hepatic function & blood counts on prolonged treatment. Risks of GI ulceration, bleeding & perforation, serious GI toxicity. Uncontrolled HTN & significant risk factors for CV disease. Pregnancy & lactation. Childn. Elderly or debilitated patients.