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Indications and Dosage
Topical/Cutaneous
Antiseptic agent Adult: To be applied topically usually in a concentration of 0.1%.
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Incompatibility
Incompatible with acids, metal ions and iodine. It forms precipitates with many alkaloids and may be adsorbed by plastic or rubber packaging materials. Activity of thiomersal may be reduced by boric acid, edetic acid or sodium thiosulfate or by the presence of blood or organic matter.
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Contraindications
Hypersensitivity.
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Special Precautions
May cause serious mercury poisoning on frequent or long-term use or application to large areas.
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Adverse Reactions
Hypersensitivity.
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Overdosage
As per mercury poisoning, gastritis, renal failure, dermatitis, gingivitis, delirium, polyneuropathy, respiratory failure and coma. Activated charcoal, chelating drugs or gastric lavage to reduce absorption. Treatment is symptomatic.
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Drug Interactions
Ocular irritation of varying degrees occurs after concomitant admin of contact lens soln containing 0.004% and oral tetracyclines.
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Action
Description:
Mechanism of Action: Thiomersal is a bacteriostatic and fungistatic mercurial antiseptic that is often used topically. Its antibacterial action results from the release of ethylmercury after breakdown to thiosalicylate and ethylmercury. It is often used as a preservative in biological and pharmaceutical products, as well as contact lens solutions in the concentration between 0.001 to 0.01%. |
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MIMS Class
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