Sertaconazole: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Tinea pedis

Adult: As 2% cream: Apply to affected and immediate surrounding areas bid for 4 weeks.

Contraindications

Hypersensitivity.

Special Precautions

Discontinue if irritation or sensitivity develop. Pregnancy and lactation.

Adverse Reactions

Contact dermatitis, dry skin, burning skin, application site reaction, skin tenderness, erythema, pruritus, vesiculation, desquamation, hyperpigmentation.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Prior to initiation of therapy, confirm diagnosis using KOH or cultures.

Monitoring Parameters

Reassess diagnosis if no clinical improvement after 2 wk.

Action

Description:
Mechanism of Action: Sertaconazole alters fungal cell wall membrane permeability. It inhibits the CYP450-dependent synthesis of ergosterol.
Pharmacokinetics:
Absorption: Minimal (topical).

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites

References

Anon. Sertaconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 15/07/2014.

Buckingham R (ed). Sertaconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 15/07/2014.

Ertaczo (sertaconazole nitrate) cream (Valeant Pharmaceuticals North America LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 15/07/2014.

Ertaczo. U.S. FDA. https://www.fda.gov/. Accessed 15/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Sertaconazole Nitrate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 15/07/2014.

Wickersham RM. Sertaconazole Nitrate - Topical. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 15/07/2014.

Disclaimer: This information is independently developed by MIMS based on Sertaconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com