Adult 250 mg every 12 hr. Severe infections May be increased up to 500 mg every 12 hr for up to 6-14 days. Renal impairment CrCl <30 mL/min Reduce dose by ½, not to exceed for 14 days.
Hypersensitivity to clarithromycin, erythromycin or macrolides. Not to be co-administered w/ ergot derivatives. Not recommended w/ astemizole. Concomitant use w/ cisapride, pimozide, terfenadine, domperidone. Pregnancy.
Discontinue use if severe acute hypersensitivity reactions occur. Not to be used in patients w/ history of acute porphyria. Pseudomembranous colitis. Cross-resistance w/ other macrolides, lincomycin, clindamycin. May affect ability to drive & use machines. Not recommended in concomitant use w/ ranitidine bismuth citrate in patients w/ CrCl <25 mL/min. Moderate to severe renal failure; hepatic impairment. Not to be used during 1st trimester of pregnancy. Lactation. Paed <6 mth. Elderly.
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