Pharmaniaga Bupivacaine 0.5%

Pharmaniaga Bupivacaine 0.5%



Pharmaniaga LifeScience


Pharmaniaga Logistics
Concise Prescribing Info
Bupivacaine HCl
Local or regional anaesth & analgesia.
Dosage/Direction for Use
Individualized dosage. Max: 2 mg/kg.
Hypersensitivity to bupivacaine or amide-type local anaesth. Not to be inj into inflamed or infected tissues nor applied to damaged skin &/or in the presence of septicaemia; not to be applied to the middle ear. Patients w/ uncorrected hypotension & complete heart block. Obstet paracervical block, IV regional anaesth (Bier's block) & all IV infusion. Lactation.
Special Precautions
Hypersensitivity. Major peripheral nerve block. Patients w/ epilepsy, impaired cardiac conduction, bradycardia, severe shock or digitalis intoxication; impaired CV function; Stokes-Adams syndrome or Wolff-Parkinson-White syndrome; preexisting neurological or neuromuscular disease eg, myasthenia gravis; serious CNS or spinal cord diseases eg, meningitis, spinal fluid block, cranial or spinal haemorrhage, tumours, poliomyelitis, syphilis, TB or metastatic spinal cord lesions; hyperthyroidism. Insert IV cannula prior to local anaesth inj. Constant monitoring of CV & resp vital signs & patient's state of consciousness after each inj. Inadvertent intravascular or subarachnoid inj; post-op IA continuous infusion. Concomitant use w/ anti-arrhythmic class III drugs eg, amiodarone. May affect ability to drive or operate machinery. Advanced hepatic disease, severe renal or hepatic impairment. Pregnancy. Childn <12 yr. Elderly, debilitated patients including w/ partial or complete conduction block.
Adverse Reactions
Lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, tinnitus, blurred vision, diplopia, nausea, vomiting, sensations of heat, cold or numbness, urinary retention, paraesthesia circumoral, paraesthesia, hyperacusis, twitching, tremors, convulsions, unconsciousness, resp depression &/or arrest, agitation, tongue numbness, difficulty swallowing, slurred speech; bradycardia, hypotension & CV collapse which may lead to cardiac arrest; maternal hypotension; spinal block of varying magnitude (including total spinal block), hypotension secondary to spinal block, loss of bladder, bowel control, perineal sensation, sexual function; backache, headache; cutaneous lesions, urticaria, oedema or anaphylactoid reactions; joint pain, stiffness, loss of motion.
Drug Interactions
Potentiation of cardiac effects w/ amide-type local anaesth eg, mexiletine, lignocaine. Caution w/ anti-arrhythmic class III drugs eg, amiodarone.
MIMS Class
Anaesthetics - Local & General
ATC Classification
N01BB01 - bupivacaine ; Belongs to the class of amides. Used as local anesthetics.
Pharmaniaga Bupivacaine 0.5% soln for inj 100 mg/20 mL
20 mL x 5 × 1's
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