Not to be used by non-smokers. Susceptibility to angioedema & urticaria. Recent MI & CVA, unstable or worsening angina, severe cardiac arrhythmias, uncontrolled HTN or hyperthyroidism, phaeochromocytoma; oesophagitis, gastric or peptic ulcers; history of epilepsy or seizures. May cause local skin reactions or eye & mucous membranes irritation due to butylated hydroxytoluene. Avoid contact w/ eyes. Monitor blood sugar levels in patients w/ DM during therapy. Concomitant use of products w/ narrow therapeutic window eg, theophylline, tacrine, clozapine, ropinirole; CYP1A2-metabolised medicinal products eg, imipramine, olanzapine, clomipramine, fluvoxamine; flecainide, pentazocine. Moderate to severe hepatic &/or severe renal impairment. May impair fertility. Pregnancy. Avoid use during lactation. Not to be used in childn & adolescents <18 yr.
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