Discontinue use if any symptoms of nicotine excess occur. Recent MI & CVA, unstable or worsening angina, severe cardiac arrhythmias, uncontrolled HTN or hyperthyroidism, phaeochromocytoma. Patients w/ oesophagitis, gastric or peptic ulcers. Monitor blood sugar levels in patients w/ DM during therapy. Remove patch prior to MRI procedures. Not recommended to use beyond 6 mth. Moderate to severe hepatic &/or severe renal impairment. Pregnancy. Avoid use during lactation. Not to be used in childn & adolescent <18 yr.