Not for IV inj. Increased risk of induced psychotic reactions & behavioural disturbances. Determine IOP & estimated anterior chamber depth of angle prior to therapy. May cause irritation due to benzalkonium Cl. Avoid contact w/ container tip & soft contact lens. Remove contact lens prior to application & wait 15 min before reinsertion. Increased susceptibility to anticholinergic drugs. Allow 5-min interval if >1 topical ophth product is used. May affect ability to drive & use machines. Hepatic & renal impairment. Not recommended during pregnancy. Lactation. Excessive use in childn. Infants, small or premature childn, childn w/ Down syndrome, spastic paralysis or brain damage.