Methdilazine

Oral
Hypersensitivity reactions, Pruritic skin disorders

May be taken with or without food.

Neonates; narrow-angle glaucoma; GI tract/urinary outflow obstruction, paralytic ileus.

Elderly; caution in driving; peptic ulcer; epilepsy; severe CV disease, benign prostatic hyperplasia; pregnancy and lactation; asthma, bronchitis; hepatic or renal impairment; Parkinson's disease.

Drowsiness, CNS depression, paradoxical excitation (children). Dry mouth, blurring of vision; constipation, retention of urine; bradycardia followed by tachycardia and arrhythmias. GI disturbances; blood dyscrasias; giddiness; hypotension; headache; asthma; tremors; photosensitivity; jaundice; menstrual disorders.

Potentiates CNS depressant action of alcohol, barbiturates, hypnotics, opioid analgesics, sedatives and neuroleptics. Antimuscarinic effects potentiated by MAOIs, atropine and TCAs. May reduce effect of levodopa.

None reported.

Description:
Mechanism of Action: Methdilazine, a phenothiazine derivative, is a sedating antihistamine with antimuscarinic and possibly some serotonin-antagonist properties.

Antihistamines & Antiallergics