Adult Monotherapy & combination w/ other oral antidiabetic agents Initially 1 tab bd or tds, adjust dose after 10-15 days based on blood glucose measurements. Max dose: 3 g daily as 3 divided doses.
Combination w/ insulin Initially 1 tab bd-tds, adjust insulin dose based on blood glucose measurements.
Childn from 10 yr & adolescent Monotherapy & combination w/ insulin Initially 500 or 850 mg once daily, adjust dose after 10-15 days based on blood glucose measurements. Max dose: 2 g daily as 2 or 3 divided doses. Total max daily dose:
Renal impairment GFR 30-44 mL/min 1,000 mg as 2-3 divided doses,
45-59 mL/min 2,000 mg as 2-3 divided doses,
60-89 mL/min 3,000 as 2-3 divided doses.
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