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Indications and Dosage
Intramuscular
Susceptible infections Adult: 2 g/day in 2 divided doses. Child: 50-100 mg/kg/day in 2-3 divided doses. Intravenous Susceptible infections Adult: 2-6 g/day in 2-3 divided doses. Child: 50-100 mg/kg/day in 2-3 divided doses. Intravenous Meningitis Child: 100 mg/kg as loading dose.
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Renal Impairment
Intravenous:
Susceptible infections: Haemodialysis patient: 15 mg/kg at end of each dialysis.
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Contraindications
Hypersensitivity.
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Special Precautions
Monitor bleeding time and give prophylaxis with vitamin K. Pregnancy and lactation. Renal impairment.
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Adverse Reactions
Hypoprothrombinaemia, serious bleeding episodes. Fever, pain at inj site, diarrhoea, cutaneous eruption, eosinophilia, leucopenia, thrombocytopenia.
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Drug Interactions
Disulfiram-like reaction with alcohol.
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Lab Interference
False-positive results for direct Coombs' test.
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Action
Description:
Mechanism of Action: Latamoxef is an oxacephalosporin with antimicrobial spectrum of activity similar to 3rd generation cephalosporins. It also inhibits beta-lactamases. Pharmacokinetics: Absorption: Well absorbed (IM). Distribution: Enters the CSF. Metabolism: Not metabolised. Excretion: Via urine (75%, as unchanged drug) and via biliary tract; 2 hr (half-life). |
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MIMS Class
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