Replacement therapy in primary immunodeficiency syndromes Starting dose: 0.4-0.8 g/kg followed by 0.2-0.8 g/kg 2-4 wkly to achieve IgG trough level of 4-6 g/L.
Replacement therapy in myeloma or chronic lymphatic leukaemia w/ severe secondary hypogammaglobulinaemia & recurrent infections; replacement therapy in childn w/ AIDS & recurrent infections 0.2-0.4 g/kg 3-4 wk.
ITP 0.8-1 g/kg on day 1, may be repeated once w/in 3 days or 0.4 g/kg daily for 2-5 days.
Guillain-Barre syndrome 0.4 g/kg daily for 3-7 days.
Kawasaki disease 1.6-2 g/kg in divided doses over 2-5 days or 2 g/kg as single dose in combination w/ ASA.
Allogeneic bone marrow transplantation 0.5 g/kg wkly starting 7 days before & up to 3 mth after transplantation for treatment of infections & prophylaxis of graft versus host disease & 0.5 g/kg mthly until Ab levels return to normal in persistent lack of Ab production.