Subacute or chronic pneumonitis; hypersensitivity; MI, CVA, thrombotic microangiopathy (haemolytic-uremic syndrome) or cerebrovascular arteritis, acute chest pain syndrome & pericarditis, fulminant fatal hyperpyrexia & angioedema. Fever, chills, headache; anorexia, nausea, vomiting, tiredness; hypoesthesia which may progress to hyperesthesia, urticaria, erythematous swelling, tenderness, pruritus, hyperpigmentation, patchy hyperkeratosis, alopecia, ichthyosis, rash, striae, vesiculation, peeling & bleeding, mucositis, stomatitis, tongue & lips ulcerations; dermal lesions (intra-arterial administration).