Adult & childn >12 yr 1.2 g 8 hrly. More serious infections Increase to 6 hrly intervals. Childn 3 mth-12 yr 30 mg/kg 8 hrly. More serious infections Increase to 6 hrly intervals. Childn 0-3 mth 30 mg/kg 12 hrly increase to 8 hrly thereafter. Surgical prophylaxisAdult Usual dose: 1.2 g at anesth induction. High risk of infection 3-4 doses of 1.2 g in 24-hr period. Moderate renal impairment (CrCl 10-30 mL/min) 1.2 g IV followed by 600 mg IV 12 hrly. Severe renally impaired adult (CrCl <10 mL/min) 1.2 g IV followed by 600 mg IV 24 hrly.
Hypersensitivity to penicillins & cephalosporins. Pseudomembranous colitis; Clostridium difficile colitis. Cholestatic jaundice. Diabetic patients. Monitor liver function at regular intervals. Avoid alcohol intake. Renal or hepatic impairment. Avoid use during 1st trimester of pregnancy. Elderly.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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