Generic Medicine Info
Indications and Dosage
Vulvovaginal candidiasis
Adult: As 2% cream: Apply approx 5 g intravaginally for 3 consecutive nights or as a single dose.
Special Precautions
Women w/ recurrent infections or those having 1st-time vag yeast infection. Childn <12 yr. Pregnancy and lactation.
Adverse Reactions
Vulvovaginal burning, itching, soreness and swelling, pelvic or abdominal pain or cramping. Severe reversible thrombocytopenia. Rarely, headache, urinary frequency and burning, vulvovaginal discharge, irritation, stinging and odor.
Patient Counseling Information
May weaken latex or rubber products (e.g. condoms, vag contraceptive diaphragms), do not use w/in 72 hr of treatment. Avoid contact w/ eyes.
Mechanism of Action: Butoconazole, a synthetic azole antifungal, is usually fungistatic in action but may have growth phase-dependent fungicidal activity at high concentrations or against very susceptible organisms. It exerts its fungistatic activity by interfering w/ ergosterol synthesis and altering cellular membranes. It also has some antibacterial activity against gm+ve organisms.
Absorption: Approx 5% is absorbed after vag use.
Excretion: Plasma half-life: 21-24 hr.
Chemical Structure

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Database. Butoconazole, CID=47472, https://pubchem.ncbi.nlm.nih.gov/compound/Butoconazole (accessed on Jan. 22, 2020)

Store between 15-30°C.
MIMS Class
Preparations for Vaginal Conditions
Anon. Butoconazole. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/07/2014.

Buckingham R (ed). Butoconazole Nitrate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/07/2014.

Gynazole Cream (Ther-Rx Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 21/07/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Butoconazole Nitrate (Vaginal). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 21/07/2014.

Wickersham RM. Butoconazole Nitrate. Facts and Comparisons [online]. St. Louis, MO. Wolters Kluwer Clinical Drug Information, Inc. https://www.wolterskluwercdi.com/facts-comparisons-online/. Accessed 21/07/2014.

Disclaimer: This information is independently developed by MIMS based on Butoconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2024 MIMS. All rights reserved. Powered by MIMS.com
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