Bulaquine


Generic Medicine Info
Indications and Dosage
Oral
Treatment and prophylaxis of relapse of Plasmodium vivax malaria
Adult: 25 mg once daily for 7 days. To be used in comjunction with chloroquine.
Contraindications
Rheumatoid arthritis; systemic lupus erythematosus. Co-administration of drugs known to cause haemolysis.
Special Precautions
Exercise caution while administering bulaquine to patients suffering from G6PD deficiency. Pregnancy and lactation, children.
Drug Interactions
Specific studies with other drugs have not been undertaken except with chloroquine where it was concurrently used in the phase II/III clinical trials without any adverse effects.
Action
Description:
Mechanism of Action: Bulaquine is a new generation of 8-aminoqinoline derivative antimalarial used in managing P. vivax infection. It reportedly inhibits protein synthesis in protozoa and polymerization of amino acids by the plasmodia. When co-administered with chloroquine, malarial is treated witho significant relapse episodes. Compared to primaquine, it requires lesser treatment days and it has better tolerance profile in patients with G6PD (G6PDH) deficiency.
MIMS Class
Antimalarials
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