Bucillamine


Generic Medicine Info
Indications and Dosage
Oral
Rheumatoid arthritis
Adult: Initially 100 mg/day.
Adverse Reactions
Skin and kidney disorders; pemiphigus lesions.
Action
Description:
Mechanism of Action: Bucillamine is structurally related to penicillamine & is reported to be an immunomodulator. It has been used in RA. It inhibits hypoxic induction of Vascular Endothelial Growth Factor (VEGF) through inhibition of Hypoxia Inducible Factor HIF-1 induction & binding activity in Bovine Retinal Microcapillary Endothelial Cells (BREC). It also inhibits the spontaneous expression of VEGF mRNA by its effect on Sp1 & Hypoxia Responsive Element (HRE) binding.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
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