Bromperidol


Generic Medicine Info
Indications and Dosage
Intramuscular
Schizophrenia, Psychoses
Adult: Long-term therapy: Up to 300 mg every 4 wk via deep inj.
Elderly: Dose reduction may be needed.

Oral
Psychoses, Schizophrenia
Adult: 1-15 mg daily, up to 50 mg daily.
Elderly: Dose reduction may be needed.
Renal Impairment
Dose reduction may be needed.
Contraindications
Coma; CNS depression; pheochromocytoma; bone marrow suppression. Pregnancy and lactation.
Special Precautions
Hepatic or renal impairment; history of jaundice; CV disease; angle-closure glaucoma; diabetes mellitus; hyperthyroidism; Parkinson's disease; epilepsy, depression, myasthenia gravis; prostatic hypertrophy; severe resp disease; blood dyscrasias. May precipitate coma, affect driving; elderly.
Adverse Reactions
Alter temp regulation; neuroleptic malignant syndrome; CNS effects (extrapyramidal effects); GI disturbances; nasal congestion; antimuscurinic symptoms; CV symptoms, endocrine effects; blood dyscrasias; photosensitization, contact sensitization and rashes; jaundice; corneal and lens opacities; purplish pigmentation of skin, cornea, conjunctiva and retina.
Drug Interactions
ACE inhibitors, α-blockers, amantadine, general anaesthetics, angiotensin-II receptor antagonists, antiarrhythmics, tricyclic antidepressants, anxiolytics and hypnotics, apomorphine, artemether with lumefantrine, barbiturates, bromocriptine, cabergoline, calcium-channel blockers, carbamazepine, cimetidine, ethosuximide, levodopa, lisuride, memantine, methyldopa, metoclopramide, opioid analgesics, oxcarbazepine, pergolide, phenytoin, pramipexole, primidone, ritonavir, ropinirole, sibutramine, sympathomimetics, terfenadine, tetrabenazine, tramadol, valproate.
Potentially Fatal: Encephalothic syndrome with concomitant use of lithium.
Action
Description:
Mechanism of Action: Bromperidol has properties similar to those of haloperidol. It is used in the treatment of schizophrenia and other psychoses.
MIMS Class
Antipsychotics
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