|
Indications and Dosage
Ophthalmic
Eye infection, bacterial Adult: As ophthalmic ointment: Apply directly into the conjunctival sac 1-3 times daily. Child: Same as adult dose. Topical/Cutaneous Bacterial skin infections Adult: For the prevention of infection in minor cuts, scrapes, or burns: As topical ointment/cream: Apply a small amount on the affected area 1-3 times daily for up to 7 days.
Child: Same as adult dose. |
|
Incompatibility
Slowly inactivated in bases containing cholesterol, polyoxyethylene derivates, stearyl alcohol, and Na laurilsulfate. Rapidly inactivated in bases containing water, benzalkonium chloride, cetylpyridinium chloride, ichthammol, macrogols, phenol, propylene glycol, and tannic acid.
|
|
Contraindications
Hypersensitivity.
|
|
Special Precautions
Patient with previous exposure to bacitracin; deep puncture wounds, animal bites, or serious burns (topical). Children. Pregnancy and lactation.
|
|
Adverse Reactions
Significant: Allergic reactions (e.g. rash), anaphylactic reactions (repeat exposure). Ophthalmic: Blurred vision, bacterial overgrowth (prolonged use).
Skin and subcutaneous tissue disorders: Rash, contact dermatitis. |
|
IM/Ophth/Parenteral/PO/Topical: C
|
|
Patient Counseling Information
The ophthalmic ointment may cause blurred vision, if affected, do not drive or operate machinery. Do not use topical ointment/cream over large areas of the body.
|
|
Action
Description:
Mechanism of Action: Bacitracin is a polypeptide antibiotic with bactericidal or bacteriostatic properties. Its antibacterial action depends on the concentration of the drug and the susceptibility of the organism. It prevents the transfer of mucopeptides into the cell wall, thereby inhibiting bacterial cell wall synthesis. Additionally, it is also active against protoplasts and disrupts bacterial plasma membrane. Pharmacokinetics: Absorption: Poorly absorbed from the mucous membranes, intact or denuded skin (topical). |
|
Storage
Topical ointment/cream: Store between 15-30°C. Ophthalmic ointment: Store between 20-25°C.
|
|
MIMS Class
|
|
ATC Classification
J01XX10 - bacitracin ; Belongs to the class of other antibacterials. Used in the systemic treatment of infections.
D06AX05 - bacitracin ; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases. |
|
References
Anon. Bacitracin (EENT). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 21/06/2023. Anon. Bacitracin (Ophthalmic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/06/2023. Anon. Bacitracin (Systemic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/06/2023. Anon. Bacitracin (Topical). AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 21/06/2023. Anon. Bacitracin (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 21/06/2023. Bacitracin Ointment (Padagis US LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 21/06/2023. Bacitracin. Gold Standard Drug Database in ClinicalKey [online]. Elsevier Inc. https://www.clinicalkey.com. Accessed 21/06/2023. Buckingham R (ed). Bacitracin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 21/06/2023. Drs. Antibiotic Bacitracin Ointment (OL Pharma Tech, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 21/06/2023. Proplex Bacitracin Cream (Natureplex LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 21/06/2023.
|
Sign Out
