Increased risk of induced psychotic reactions & behavioural disturbances. Determine IOP & estimated anterior chamber depth of angle prior to therapy. Light sensitivity. May cause irritation due to benzalkonium Cl. Febrile patients exposed to elevated environmental temp. Avoid contact w/ container tip & soft contact lens. Remove contact lens prior to application & wait 15 min before reinsertion. Increased susceptibility to anticholinergic drugs. Allow 5-min interval if >1 topical ophth product is used. Excessive & prolonged use. May affect ability to drive & use machines. Hepatic & renal failure. Not recommended in women of childbearing potential & during pregnancy. Not to be used during lactation. Older childn, premature & low birth wt childn, w/ Down syndrome, spastic paralysis or brain damage; fair-skinned childn w/ blue eyes. Elderly.