Fever, Pain
Adult: 325-650 mg 3-4 times daily.
Topical/Cutaneous
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As rubefacient preparations: Up to 5% to be applied as directed.
Indications and Dosage
Oral
Fever, Pain Adult: 325-650 mg 3-4 times daily. Topical/Cutaneous Pain and inflammation associated with musculoskeletal and joint disorders Adult: As rubefacient preparations: Up to 5% to be applied as directed.
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Contraindications
Severe renal or hepatic impairment.
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Special Precautions
Pregnancy and lactation. Dyspepsia, uncontrolled hypertension, G6PD deficiency and children .
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Adverse Reactions
CNS disturbances, GI disturbances, flushing, hyperventilation, sweating, dry mouth, rash and thrombocytopenic purpura. Tinnitus, ecchymosis, haemorrhagic lesions, leukopenia or thrombocytopenia in high doses.
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Drug Interactions
Serum levels may be reduced when used with corticosteroids. Increased risk of adverse effects when used with other NSAIDs.
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Lab Interference
May interfere with thyroid function tests.
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Action
Description:
Mechanism of Action: Salicylamide is a salicylic acid derivative but it is not hydrolysed to salicylate. Salicylate-like analgesic and antipyretic effects are inconsistent due to rapid and extensive metabolism during absorption. It may also produce hypotensive effects, through dilation of peripheral blood vessels, and CNS depression. Pharmacokinetics: Metabolism: Almost completely metabolised to inactive metabolites during absoption and first pass through the liver. |
MIMS Class
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