Penciclovir: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Recurrent herpes simplex labialis

Adult: As 1% cream: Appy 2 hrly during waking hr (approx 8 times daily) for 4 days. Initiate treatment at earliest sign or symptom.
Child: >12 yr Same as adult dose.

Contraindications

Hypersensitivity to penciclovir, famciclovir.

Special Precautions

Immunocompromised patients (e.g. AIDS patients, bone marrow transplant recipients). Not recommended for application to mucous membranes (e.g. eyes, mouth, nose, genitals). Pregnancy and lactation.

Adverse Reactions

Headache, taste perversion, application site reactions (e.g. stinging, burning, numbness), pruritus, pain, rash, allergic reactions, contact dermatitis.

Pregnancy Category (US FDA)

Topical: B

Monitoring Parameters

Monitor reduction in virus shedding, negative cultures for herpes virus; resolution of pain and healing of cold sore lesion.

Action

Description:
Mechanism of Action: Penciclovir has in vitro and in vivo inhibitory activity against various Herpesviridae, including herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), and EpsteinBarr virus (EBV). In cells infected w/ HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form which, in turn, is converted to penciclovir triphosphate by cellular kinases. Penciclovir triphosphate inhibits HSV polymerase competitively w/ deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.
Pharmacokinetics:
Absorption: Not absorbed appreciably into systemic circulation following topical administration at single or multiple doses up to a total of 180 mg (approx 67 times the proposed daily clinical dose).

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Topical Antivirals

References

Anon. Penciclovir. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 25/11/2014.

Buckingham R (ed). Penciclovir. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 25/11/2014.

Denavir Cream (Novartis Consumer Health Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 25/11/2014.

McEvoy GK, Snow EK, Miller J et al (eds). Penciclovir (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 25/11/2014.

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