Pemirolast: Indication, Dosage, Side Effect, Precaution

This information is not country-specific. Please refer to the Indonesia prescribing information.

Generic Medicine Info

Indications and Dosage

Ophthalmic
Prophylaxis of allergic conjunctivitis

Adult: As 0.1% ophthalmic solution: Instill 1-2 drops into the affected eye(s) 4 times daily.
Child: >3 yr: As 0.1% ophthalmic solution: Instill 1-2 drops into the affected eye(s) 4 times daily.

Oral
Allergic rhinitis

Adult: Usual dose: 5 mg bid.
Child: 1-4 yr: 1.25 mg bid; 5-10 yr: 2.5 mg bid.

Oral
Chronic asthma

Adult: Usual dose: 10 mg bid.
Child: 1-4 yr: 2.5 mg bid; 5-10 yr: 5 mg bid.

Special Precautions

Not for treatment of contact lens-related irritation. Contact lens should be removed prior to drug admin and reinserted only at least 10 minutes after application. Safety and efficacy have not been established in children <3 yr. Pregnancy and lactation.

Adverse Reactions

Headache, rhinitis, cold/flu symptoms, bronchitis, cough, sinusitis, sneezing/nasal congestion. Ocular application: Burning, dry eye, foreign body sensation and ocular discomfort.

Pregnancy Category (US FDA)

Ophth: C

Action

Description:
Mechanism of Action: Pemirolast is a mast cell stabiliser that inhibits the in vivo Type I immediate hypersensitivity reaction. It inhibits chemotaxis of eosinophils into the ocular tissue and blocks the release of mediators. It is also reported to prevent calcium influx into mast cells following antigen stimulation. It has also been used in the treatment of chronic asthma and prophylaxis of allergic rhinitis.
Onset: Ocular application: A few days.
Pharmacokinetics:
Excretion: Elimination half-life: 4.5 hr. About 10-15% is excreted in urine.

Storage

Store at 15-25°C.

MIMS Class

Antiasthmatic & COPD Preparations / Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories

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