SC Women w/ anovulation (including PCOS) Individualized dosage. Start w/in initial 7 days of menstrual cycle. Initially 75-150 IU daily, preferably increased by 37.5 or 75 IU at 7 or 14 day intervals. Max: 225 IU daily. Single inj of 5,000-10,000 IU HCG is given 24-48 hr after the last inj when an optimal response is obtained.
Women undergoing ovarian stimulation for multiple follicular development prior to in vitro fertilisation or other assisted reproductive technologies Superovulation 150-225 IU commencing on days 2 or 3 of the cycle, continued until adequate follicular development has been achieved. Max: 450 IU daily. Duration: 5-20 days. Single inj of up to 10,000 IU HCG is administered 24-48 hr after the last inj to induce final follicular maturation.
Women w/ anovulation resulting from severe LH & FSH deficiency Initially 75 IU of lutropin α daily w/ 75-150 IU FSH. FSH dose may increase after 7-14 day intervals & by 37.5-75 IU increments. Max duration: 5 wk. Single inj of 5,000-10,000 IU HCG is given 24-48 hr after the last FSH & lutropin α inj when an optimal response is obtained. Alternatively, intrauterine insemination (IUI) may be performed.
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