Adjunctive therapy epilepsy Adult Initially 25-50 mg nightly for 1 wk. Subsequently, at wkly or bi-wkly intervals, the dose should be increased by 25-50 (to 100) mg/day & taken in 2 divided doses.
Childn ≥2 yr 5-9 mg/kg/day in 2 divided doses. Titration should begin at 1-3 mg/kg/day nightly for the 1st wk, thereafter increased at 1-2 wk intervals by increments of 1-3 mg/kg/day given in 2 divided doses.
Monotherapy epilepsy Adult Initially 25 mg nightly for 1 wk, thereafter increased at 1-2 wk intervals by increments of 25-50 mg/day, given in 2 divided doses. Recommended initial target dose: 100 mg/day, max daily dose: 500 mg.
Childn ≥2 yr Initially 0.5-1 mg/kg nightly for the 1st wk, thereafter increased at 1-2 wk intervals by increments of 0.5-1 mg/kg/day, given in 2 divided doses. Recommended initial target dose: 3-6 mg/kg/day.
Prophylaxis of migraine headache Initially 25 mg nightly for 1 wk increased at 25 mg/day increments at 1 wk intervals. Recommended total daily dose: 100 mg/day in 2 divided doses.
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