AdultHTN 50-100 mg daily as a single dose. Angina 100 mg once daily or 50 mg bd. Cardiac arrhythmias Maintenance: 50-100 mg once daily a single dose. MI Early intervention w/in 12 hr of infarction: 5-10 mg by slow IV inj, followed by 50 mg orally after 15 min, 50 mg orally after 12 hr & then 12 hr later 100 mg orally once daily.
Poor cardiac reserve, Prinzmetal's angina, 1st degree heart block, reversible obstructive airways disease. May aggravate less severe peripheral arterial circulatory disturbances. May modify tachycardia or hypoglycaemia. May mask signs of thyrotoxicosis. Avoid abrupt discontinuation in patients w/ ischaemic heart disease. History of anaphylactic reaction to allergens, renal impairment. May increase airways resistance in asthmatics. Pregnancy & lactation. Elderly.
Adverse Reactions
Bradycardia, heart failure deterioration, postural hypotension, cold extremities, precipitation of heart block, intermittent claudication, Raynaud's phenomenon; confusion, dizziness, headache, mood changes, nightmares, psychoses, hallucinations, sleep disturbances; dry mouth, GI disturbances; elevation of transaminase levels, hepatic toxicity including intrahepatic cholestasis; purpura, thrombocytopenia; alopecia, dry eyes, psoriasiform skin reactions, exacerbation of psoriasis, rash; paraesthesia; bronchospasm; visual disturbances; fatigue, increased in ANA.
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