Adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non-HDL-C, & triglycerides & increase HDL-C in adults w/ primary hyperlipidemia or mixed dyslipidemia when response to diet & nonpharmacological interventions alone has been inadequate; reduce total-C, LDL-C, & ApoB levels in adolescents 10-17 yr (boys & 1-yr post-menarchal girls) w/ heterozygous familial hypercholesterolemia if LDL-C >190 or >160 mg/dL after an adequate trial of diet therapy & there is +ve family history of premature CV disease (CVD) or ≥2 other CVD risk factors. Adjunct to diet for adults w/ hypertriglyceridemia; primary dysbetalipoproteinemia (type III hyperlipoproteinemia). Adjunct to other lipid-lowering treatments (eg, LDL apheresis) or alone if such treatments are unavailable to reduce LDL-C, total-C, & ApoB in adults w/ HoFH. Adjunct to diet to lower total-C & LDL-C to target levels & slow the progression of atherosclerosis in adults. Reduce risk of stroke, MI & arterial revascularization procedures in individuals w/o clinically evident CHD but w/ increased risk of CVD based on age (men ≥50 yr & women ≥60 yr), hsCRP ≥2 mg/L, & presence of at least 1 additional CVD risk factor eg, HTN, low HDL-C, smoking, or family history of premature CHD.