Oesophageal reflux disease including reflux oesophagitis 20 mg once daily, can also be administered at 40 mg once daily in patients w/ reflux oesophagitis refractory to other therapy. Duration of treatment: 4-8 wk.
Acid reflux disease 10 mg once daily for long-term treatment, increasing to 20 mg if symptoms return.
Duodenal & benign gastric ulcers 20 mg once daily, may be increased to 40 mg once daily for severe or recurrent cases. Duration of therapy: 8 wk.
Prevention of relapse in patients w/ duodenal ulcer 10 mg once daily, increasing to 20 mg once daily if symptoms return.
Patient w/ H. pylori infection, patient <60 yr; symptoms persist for ≥1 yr & smokers Initially 20 mg once daily, reducing to 10 mg once daily.
H. pylori eradication in PUD 40 mg once daily or 20 mg bd in combination w/ amoxicillin 500 mg & metronidazole 400 mg tds for 1 wk or clarithromycin 250 mg & metronidazole 400 mg (or tinidazole 500 mg) bd for 1 wk or amoxicillin 1 g & clarithromycin 500 mg bd for 1 wk or amoxicillin 750 mg to 1 g bd for 2 wk.
Prophylaxis of acid aspiration 40 mg on the evening before surgery followed by 40 mg 2-6 hr prior to surgery.
Zollinger-Ellison syndrome Initially 60 mg once daily. Dose should be adjusted individually & treatment continued as long as clinically indicated.
Childn >2 yr Severe ulcerating reflux oesophagitis 0.7-1.4 mg/kg daily. Max: 40 mg/day for 4-12 wk.
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