History of hypersensitivity to carbapenems, penicillins or other β-lactam antibiotics. Discontinue if severe allergic reaction occurs. Immediately w/draw & consider alternative treatment if signs & symptoms suggestive of severe cutaneous adverse reactions eg, SJS, TEN, DRESS, erythema multiforme & acute generalised exanthematous pustulosis appear. Reports of antibiotic-associated colitis & pseudomembranous colitis; seizures. Risk of hepatic toxicity. Closely monitor hepatic function during treatment. May develop a +ve direct or indirect Coombs test. Not recommended w/ valproic acid/Na valproate/valpromide. Patients on a controlled Na diet. Patient w/ renal impairment. May affect ability to drive & use machines. Avoid during pregnancy. Should not be used in breast-feeding women. Childn <3 mth.