Adults & childn ≥40 kg Intermittent administration Broncho-pulmonary infections in cystic fibrosis 100-150 mg/kg/day every 8 hr. Max: 9 g/day.
Febrile neutropenia, nosocomial pneumonia, bacterial meningitis, bacteraemia 2 g every 8 hr.
Bone & joint infections, complicated skin & soft tissue infections, complicated intra-abdominal infections, peritonitis associated w/ dialysis in patients on CAPD 1-2 g every 8 hr.
Complicated UTI 1-2 g every 8 hr or 12 hr.
Peri-operative prophylaxis for TURP 1 g at induction of anaesth, & a 2nd dose at catheter removal.
Chronic suppurative otitis media, malignant otitis externa 1-2 g every 8 hr.
Continuous infusion Febrile neutropenia, nosocomial pneumonia, broncho-pulmonary infections in cystic fibrosis, bacterial meningitis, bacteraemia, bone & joint infections, complicated skin & soft tissue infections, complicated intra-abdominal infections, peritonitis associated w/ dialysis in patients on CAPD Loading dose 2 g followed by a continuous infusion of 4-6 g every 24 hr.
Infant & toddlers >2 mth & childn <40 kg Intermittent administration Complicated UTI, chronic suppurative otitis media, malignant otitis externa 100-150 mg/kg/day in 3 divided doses, max 6 g/day.
Neutropenic childn, broncho-pulmonary infections in cystic fibrosis, bacterial meningitis, bacteraemia 150 mg/kg/day in 3 divided doses, max 6 g/day.
Bone & joint infections, complicated skin & soft tissue infections, complicated intra-abdominal infections, peritonitis associated w/ dialysis in patients on CAPD 100-150 mg/kg/day in 3 divided doses, max 6 g/day.
Continuous infusion Febrile neutropenia, nosocomial pneumonia, broncho-pulmonary infections in cystic fibrosis, bacterial meningitis, bacteraemia, bone & joint infections, complicated skin & soft tissue infections, complicated intra-abdominal infections, peritonitis associated w/ dialysis in patients w/ CAPD Loading dose 60-100 mg/kg followed by a continuous infusion 100-200 mg/kg/day, max 6 g/day.
Neonate & infant ≤2 mth Intermittent administration Most infections 25-60 mg/kg/day in 2 divided doses.
Elderly >80 yr Daily dose should not normally exceed 3 g.
Renal impairment Initial loading dose of 1 g. Maintenance: Based on CrCl.
Intermittent administration Adult & childn ≥40 kg CrCl 31-50 mL/min 1 g 12 hrly;
16-30 mL/min 1 g 24 hrly;
6-15 mL/min 0.5 g 24 hrly;
<5 mL/min 0.5 g 48 hrly.
Childn <40 kg CrCl 31-50 mL/min 25 mg/kg 12 hrly;
16-30 mL/min 25 mg/kg 24 hrly;
6-15 mL/min 12.5 mg/kg 24 hrly;
<5 mL/min 12.5 mg/kg 48 hrly.
Continuous infusion Adult & childn ≥40 kg CrCl 31-50 mL/min Loading dose 2 g followed by 1-3 g/24 hr;
16-30 mL/min Loading dose 2 g followed by 1 g/24 hr.