Cravit 250/Cravit IV

Cravit 250/Cravit IV

levofloxacin

Manufacturer:

Daiichi Sankyo

Distributor:

Zuellig
/
Agencia Lei Va Hong
Concise Prescribing Info
Contents
Levofloxacin
Indications/Uses
Treatment of adults (≥18 yr) w/ mild, moderate, & severe infections caused by susceptible strains: Acute bacterial sinusitis due to Strep pneumoniae, H. influenzae, or Moraxella catarrhalis; acute bacterial exacerbation of chronic bronchitis due to Staph aureus, Strep pneumoniae, H. influenzae, H. parainfluenzae, or Moraxella catarrhalis; nosocomial pneumonia due to methicillin-susceptible Staph aureus, Pseudomonas aeruginosa, Serratia marcescens, E. coli, Klebsiella pneumoniae, H. influenzae, or Strep pneumoniae; community-acquired pneumonia due to Staph aureus, Strep pneumoniae (including multidrug resistant strains), H. influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneumoniae, Legionella pneumophila, or Mycoplasma pneumoniae; complicated skin & soft tissue infections due to methicillin-susceptible Staph aureus, Enterococcus faecalis, Strep pyogenes, Proteus mirabilis; uncomplicated skin & soft tissue infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma wound infections, due to Staph aureus or Strep pyogenes; chronic bacterial prostatitis due to E. coli, Enterococcus faecalis, or Staph epidermidis; complicated UTI (mild to moderate) due to Enterococcus faecalis, Enterobacter cloacae, E. coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa; acute pyelonephritis (mild to moderate) caused by E. coli; uncomplicated UTI (mild to moderate) due to E. coli, Klebsiella pneumoniae, or Staph saprophyticus. Prevention of development of inhalational anthrax following exposure to Bacillus anthracis.
Dosage/Direction for Use
PO/IV Community-acquired pneumonia 500 mg 24 hrly for 7-14 days or 750 mg 24 hrly for 5 days (for infections caused by Strep pneumoniae, Staph aureus, Klebsiella pneumoniae, Moraxella catarrhalis, Legionella pneumophila, H. influenzae, H. parainfluenzae, Mycoplasma pneumoniae & Chlamydia pneumoniae). Nosocomial pneumonia & complicated skin & soft tissue infection 750 mg 24 hrly for 7-14 days. Acute bacterial exacerbation of chronic bronchitis 500 mg 24 hrly for 7 days. Acute bacterial sinusitis 500 mg 24 hrly for 10-14 days or 750 mg 24 hrly for 5 days. Uncomplicated skin & soft tissue infection 500 mg 24 hrly for 7-10 days. Chronic bacterial prostatitis 500 mg 24 hrly for 28 days. Complicated UTI & acute pyelonephritis 250 mg 24 hrly for 10 days. Uncomplicated UTI 250 mg 24 hrly for 3 days. Inhalational anthrax (post-exposure) 500 mg 24 hrly for 60 days. Sequential IV to PO therapy may be instituted. IV route to be given via slow IV infusion only over 60-90 min depending on the dose. Dose adjustment may be required in cases of altered renal function.
Administration
May be taken with or without food: Take at least 2 hr before or after Fe salts, antacids & sucralfate. Ensure adequate fluid intake.
Contraindications
Hypersensitivity to levofloxacin & other quinolones.
Special Precautions
Disabling & potentially irreversible serious adverse reactions including tendinitis & tendon rupture, peripheral neuropathy, & CNS effects. Exacerbation of myasthenia gravis. Congenital long QT syndrome, hypokalaemia, hypomagnesaemia, heart failure, MI, bradycardia. Known or suspected CNS disorders. Hypersensitivity reactions. Pseudomembranous colitis. Ensure adequate hydration. Moderate to severe phototoxicity. Vision disorders. Aortic aneurysm & dissection. Monitor blood glucose levels. DM. Periodic assessment of renal, hepatic & haematopoietic functions. Pregnancy & lactation. Childn & adolescents <18 yr. Elderly.
Adverse Reactions
Nausea, headache, diarrhea, insomnia, constipation, abdominal pain, dizziness, vomiting, dyspepsia, vaginitis, rash, chest pain, pruritus, sinusitis, dyspnea, fatigue, flatulence, pain, back pain, rhinitis, anxiety, pharyngitis.
Drug Interactions
Increased risk of QT interval prolongation w/ class IA & III antiarrhythmics, TCAs, macrolides, antipsychotics. Monitor theophylline levels. Potential enhanced effects of warfarin. Increased risk of CNS stimulation & convulsive seizures w/ NSAIDs. Potential disturbances of blood glucose w/ antidiabetics. FC tab: Allow at least 2-hr interval ie, before or after administration of antacids, sucralfate, metal cations & multivit. IV infusion: Do not co-administer w/ any soln containing multivalent cations through the same IV line.
MIMS Class
Quinolones / Urinary Antiseptics
ATC Classification
J01MA12 - levofloxacin ; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.
Presentation/Packing
Form
Cravit 250 FC tab 250 mg
Packing/Price
10 × 10's
Form
Cravit IV infusion 500 mg/100 mL
Packing/Price
1's
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in
Exclusive offer for doctors
Register for a MIMS account and receive free medical publications worth $768 a year.
Already a member? Sign in