Cotiasar Dosage & Drug Information

Concise Prescribing Info

Contents

Losartan K 50 mg, hydrochlorothiazide 12.5 mg

Indications/Uses

Management of HTN.

Dosage/Direction for Use

1 tab once daily, may increase to 2 tab once daily.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to losartan K, hydrochlorothiazide & other sulfonamide-derived drugs; anuria. Pregnancy.

Special Precautions

Hepatic or severe renal impairment. Hypotension & electrolyte/fluid imbalance. Adjust dose antidiabetics & insulin if taken concomitantly. Discontinue prior to parathyroid function tests. Patient at risk of hyperuricemia &/or gout, at risk of SLE exacerbation/activation. Lactation. Childn.

Adverse Reactions

Dizziness, asthenia/fatigue, vertigo.

View ADR Monitoring Form

Drug Interactions

Reduced lithium excretion. Reduced effect w/ NSAIDs. Reduced levels of losartan w/ rifampicin & fluconazole. Increased serum K levels w/ K-sparing diuretics, K supplements or salt substitutes containing K. Potentiation of orthostatic hypotension w/ alcohol, barbiturates, narcotics. Additive effect w/ other antihypertensives. Impaired hydrochlorothiazide absorption w/ cholestyramine, colestipol resins. Intensify hypokalemia w/ corticosteroids, ACTH or glycyrrhizin. Decreased response to pressor amines. Increased responsiveness to muscle relaxant w/ nondepolarizing skeletal muscle relaxants.

MIMS Class

Angiotensin II Antagonists / Diuretics

ATC Classification

C09DA01 - losartan and diuretics ; Belongs to the class of angiotensin II receptor blockers (ARBs) in combination with diuretics. Used in the treatment of cardiovascular disease.

Regulatory Classification

P₁S₁S₃

Presentation/Packing

Form

Cotiasar tab 50 mg/12.5 mg

Packing/Price

6 × 10's

Cotiasar

losartan + hydrochlorothiazide

Manufacturer:

Tecnimede

Distributor:

Firma Welfare Instrument

T-BOMA