Adult Treatment of HSV infections 200 mg 5 times daily at approx 4-hrly intervals (omit night time dose). Continue treatment for 5 days; may be extended in severe initial infections. In severely immunocompromised patients (eg, after marrow transplant) or in patient w/ impaired absorption from the gut, dose can be doubled to 400 mg.
Suppression of HSV infections in immunocompetent patients 200 mg qds at approx 6-hrly intervals or 400 mg bd at approx 12-hrly intervals. Dose can be titrated down to 200 mg tds at approx 8-hrly intervals or bd at approx 12-hrly intervals.
Prophylaxis of HSV infections in immunocompromised patients 200 mg qds at approx 6-hrly intervals. In severely immunocompromised patients (eg, after marrow transplant) or in patient w/ impaired absorption from the gut, dose can be doubled to 400 mg.
Treatment of varicella & HZV infections 800 mg 5 times daily at approx 4-hrly intervals (omit night time dose). Continue treatment for 7 days.
Paed population Treatment of HSV infections & prophylaxis of HSV infections in the immunocompromised Childn ≥2 yr Adult dose,
<2 yr Half of the adult dose.
Treatment of varicella infection Childn ≥6 yr 800 mg qds,
2-5 yr 400 mg qds,
<2 yr 200 mg qds. Continue treatment for 5 days. Dosing may be more accurately calculated as 20 mg/kg. Max: 800 mg qds.
Patients w/ renal impairment Management of HSV infections Severe renal impairment (CrCl <10 mL/min) 200 mg bd at approx 12-hrly intervals.
Treatment of HZV infections Severe renal impairment (CrCl <10 mL/min) 800 mg bd at approx 12-hrly intervals,
moderate renal impairment (CrCl 10-25 mL/min) 800 mg tds at approx 8-hrly intervals.
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