Individualized dosage. Recommended starting dose: 1.3 mg/m2 administered either as 3-5 sec IV bolus or SC inj. Multiple myeloma Retreatment: Start at the last tolerated dose. Moderateor severe hepatic impairment Use lower starting dose.
Discontinue use if peripheral neuropathy occurs. Pre-existing severe neuropathy; hypotension; dehydration. History of syncope. Concomitant use w/ antihypertensives.
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