Schizophrenia Adult Recommended starting & target dose: 10 or 15 mg once daily. Dose range: 10-30 mg daily. Dose increases should not be made before 2 wk (time needed to achieve steady state).
Adolescent Recommended target dose: 10 mg daily. Initially 2 mg daily, titrate to 5 mg daily after 2 days & to the target dose of 10 mg daily after 2 additional days. Subsequently increase dose in 5 mg increments.
Bipolar disorder Adult Recommended starting dose: Monotherapy: 15 mg once daily. Adjunctive therapy w/ lithium or valproate: 10-15 mg once daily. Recommended target dose for mono- & adjunctive therapy: 15 mg daily. Dose may be increased to 30 mg daily. Maintenance dose: Same dose needed to stabilize patient during acute treatment.
Adolescent Recommended starting dose: Monotherapy: 2 mg daily, titrate to 5 mg daily after 2 days & a target dose of 10 mg daily after 2 additional days. Subsequently increase dose in 5 mg daily increments if needed. Maintenance dose: Same dose needed to stabilize patient during acute treatment.
Irritability associated w/ autistic disorder Paed 6-17 yr Recommended dose range: 5-15 mg daily. Initially 2 mg daily, increase to 5 mg daily & subsequently to 10-15 mg daily if needed. Gradually adjust dose up to 5 mg daily at intervals of no <1 wk.
Tourette's disorder Paed 6-18 yr Recommended dose range: 5-20 mg daily.
Patient ≥50 kg Initially 2 mg daily for 2 days, increase to 5 mg daily for 5 days, w/ a target dose of 10 mg daily on day 8. Can be increased up to 20 mg daily. Gradually adjust dose in 5 mg daily increments at intervals of no <1 wk. <
50 kg Initially 2 mg daily, w/ a target dose of 5 mg daily after 2 days. Can be increased up to 10 mg daily. Gradually adjust dose at intervals of no <1 wk.
Adjunctive therapy to antidepressants for MDD Recommended starting dose: 2-5 mg daily. Recommended dosage range: 2-15 mg daily. Dosage adjustments of up to 5 mg daily should occur gradually at intervals of no <1 wk.