Discontinue therapy if CK levels are markedly elevated (>10 x ULN) or if myopathy is diagnosed or suspected. Patients w/ predisposing factors for myopathy eg, renal impairment, advanced age & hypothyroidism or situations where an increase in plasma levels may occur. Temporarily w/held therapy in patients w/ an acute serious condition suggestive of myopathy or predisposing to the development of renal failure secondary to rhabdomyolysis (eg, sepsis, hypotension, major surgery, trauma, severe metabolic, endocrine & electrolyte disorders; uncontrolled seizures). Concomitant use w/ ciclosporin, fibric acid derivatives (including gemfibrozil), nicotinic acid, azole antifungals, & macrolides; daptomycin; gemfibrozil; fenofibrate & other fibrates; anticoagulant. DM. Patients who consume excessive quantities of alcohol &/or have a history of liver disease. Not recommended in patients w/ moderate or severe hepatic impairment. Asians.
Sign Out
