Zifam CS1/CS2

Zifam CS1/CS2

cefoperazone + sulbactam


Zifam Pinnacle


Concise Prescribing Info
Per Zifam CS1 vial Sulbactam Na 500 mg, cefoperazone Na 500 mg. Per Zifam CS2 vial Sulbactam Na 1000 mg, cefoperazone Na 1000 mg
Treatment of infections eg resp tract infections (upper & lower); UTI (upper & lower); peritonitis, cholecystitis, cholangitis & other intra-abdominal infections; septicemia; meningitis; skin & soft tissue infections; bone & joint infections; pelvic inflammatory disease, endometriosis, gonorrhea & other genital tract infections. Alone or in in combination w/ other antibiotics.
Dosage/Direction for Use
Adult 2-4 g/day IV or IM 12 hrly. Severe or refractory infections Max: 8 g/day. Patients w/ CrCl 15-30 mL/min Max daily dose: 2 g sulbactam, CrCl <15 mL/min Max daily dose: 1 g sulbactam. Childn 40-80 mg/kg/day (ie 20-40 mg/kg/day cefoperazone activity) in 2-4 equally divided doses. Serious or refractory infections Max: 160 mg/kg/day (ie 80 mg/kg/day cefoperazone activity) in 2-4 equally divided doses. Neonates (1st wk of life) 12 hrly.
Hypersensitivity to penicillins or cephalosporins.
Special Precautions
Hepatic disease, biliary obstruction, renal dysfunction. Risk of vit K deficiency. Prolonged use may cause an overgrowth of nonsusceptible organisms. Check periodically the renal, hepatic & hematopoietic systems particularly in neonates. Alcohol consumption. Pregnancy & lactation.
Adverse Reactions
Diarrhea, nausea, vomiting, maculopapular rash, urticaria, decreased Hb & hematocrit, transient eosinophilia, thrombocytopenia, hypoprothrombinemia, transient elevations of liver function tests.
MIMS Class
ATC Classification
J01DD62 - cefoperazone and beta-lactamase inhibitor ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Zifam CS1 injectable powd
1 g x 1's
Zifam CS2 injectable powd
2 g x 1's
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