Zefopenam Drug Interactions

Probenecid competes with meropenem for active tubular secretion and thus, inhibits the renal excretion with the effect of increasing the elimination t_½ and plasma concentration of meropenem. As the potency and duration of action of meropenem dosed without probenecid are adequate, the co-administration of probenecid with meropenem is not recommended. The potential effect of meropenem on the protein-binding of other drugs or metabolism has not been studied. The protein-binding of meropenem is low (approximately 2%) and therefore, no interactions with other compounds based on displacement from plasma proteins would be expected. Meropenem has been administered concomitantly with other medications without adverse pharmacological interactions. Meropenem may reduce serum valproic acid levels. Subtherapeutic levels may be reached in some patients. However, no specific data regarding potential drug interactions is available.
Incompatibilities: Meropenem should not be mixed with or added to other drugs.
Meropenem is compatible with the following infusion fluids: Sodium chloride 0.9% solution, glucose 5% or 10 % solution, glucose 5% solution with sodium bicarbonate 0.02%, sodium chloride 0.9% and glucose 5% solution, glucose 5% solution with sodium chloride 0.225% solution, glucose 5% solution with potassium chloride 0.15% solution, and mannitol 2.5% or 10% solution.