Zefopenam Dosage/Direction for Use

Adults: Dosage and duration of therapy shall be established depending on type and severity of infection and the condition of the patient. Recommended Dose: Pneumonia, Urinary Tract Infections, Gynaecological Infections eg, Endometritis, Skin and Skin Structure Infections: 500 mg IV every 8 hrs. Nosocomial Pneumonias, Peritonitis, Presume Infections in Neutropenic Patients, Septicaemia: 1 g IV every 8 hrs. Meningitis: 2 g every 8 hrs.
As with other antibiotics, particular caution is recommended in using meropenem as monotherapy in critically ill patients with known or suspected Pseudomonas aeruginosa lower respiratory tract infection.
Regular sensitivity testing is recommended when treating Pseudomonas aeruginosa infection.
Dosage schedule for adults with impaired renal function dosage should be reduced in patients with creatinine clearance (CrCl) <51 mL/min as scheduled in the table as follows (see Table 2).

Click on icon to see table/diagram/image

Meropenem is cleared by haemodialysis. If continued treatment with meropenem is necessary, it is recommended that the unit dose (based on the type and severity of infection) is administered at the completion of the haemodialysis procedure to restore therapeutically effective plasma concentrations.
There is no experience with the use of meropenem in patients under peritoneal dialysis.
Children (>3 Months to 12 Years): Recommended Dose: 10-20 mg/kg every 8 hrs depending on type and severity of infection, susceptibility of the pathogen and the condition of the patient. Children >50 kg: Adult dose should be used. Meningitis: 40 mg/kg every 8 hrs. There is no experience in children with renal impairment.
Elderly: No dosage adjustment is required for elderly with normal renal function or creatinine clearance values >50 mL/min.
Hepatic Insufficiency: No dosage adjustment is necessary in patients with hepatic insufficiency.
Administration: Meropenem IV can be given as an IV bolus injection over approximately 5 min or by IV infusion over approximately 15-30 min using the specific available presentation.
Meropenem IV to be used for bolus IV injection should be constituted with sterile water for injection (meropenem 5 mL/250 mg). This provides an approximately concentration of 50 mg/mL. Constituted solutions are clear and colourless or pale yellow. Meropenem IV for IV infusion may be constituted with compatible infusion fluid (50-200 mL).