Zefopenam Adverse Reactions

Serious adverse events are rare. During the clinical trials the following adverse events have been reported: Local IV Injection Site Reactions: Inflammation, thrombophlebitis, pain at the site of injection.
Systemic Allergic Reactions: Rarely, systemic allergic reactions (hypersensitivity) may occur following administration of meropenem.
These reactions may include angioedema and manifestations of anaphylaxis.
Skin Reactions: Rash, pruritus, urticaria, rarely, severe skin reactions eg, erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis, have been observed.
Gastrointestinal: Abdominal pain, nausea, vomiting, diarrhea, pseudomembranous colitis have been reported.
Blood: Reversible thrombocytopenia, eosinophilia, thrombocytopenia, leucopenia and neutropenia (including very rare cases of agranulocytosis). A positive direct or indirect Coombs test may develop in some subjects; there have been reports of reduction in partial thromboplastin time.
Liver Function: Increases in serum concentrations of bilirubin transaminases, alkaline phosphatase and lactic dehydrogenase alone or in combinations have been reported.
Central Nervous System: Headache, paraesthesia. Infrequently convulsions have been reported although a casual relationship with meropenem has not been established.
Other: Oral and vaginal candidiasis.